INOSITOL ARGININE SILICATE
Real innovation these days is hard to come by but fortunately Gaspari R&D was able to get their hands on this revolutionary form of clinically studied patented arginine called inositol arginine silicate (aka Nitrosigine). By itself, arginine has a poor bioavailability when taken orally due to enzymes called arginases which break it down. By attaching inositol and silicon to the molecule, it's able to avoid a high degree of degradation and increase blood vessel relaxation 5x greater than arginine hcl and increase blood flow almost 2x greater in animal models.*
A little known fact to most athletes is that the mineral silicon serves an important role in your cardiovascular system as a host of other benefits throughout the body. Silicon has been shown to be a critical component to arterial wall strength and integrity.
In the case of Nitrosigine, the silicon component helps increase blood levels greatly which may support increased blood flow observed when taking pre-training.*
Additionally, human trials have looked at the effects of Nitrosigine on proteomics. The study found that Nitrosigine positively affected certain proteins that are associated with cardiovascular health, including vasodilation.* This powerful ingredients helps drive the “pump” in SuperPump to levels never seen before and in ways which were once thought not possible.*
This novel arginine derivative was specifically spec'd into the SuperPump 3.0 by Rich Gaspari himself. The reason being, it supports strong pumps.* It works by binding to the alpha2-adrenergic and imidazole receptors of endothelial cells increasing nitric oxide (NO) production which may assist in volumizing blood vessels.* Agmatine has become one of the must have “pump agents” in many pre-workouts. However, it is also extremely expensive but Rich is a man of his word and wants to put out solid products which is why we use 500 mg per serving.
Choline itself has a wealth of health and wellness benefits but we use it in SuperPump 3.0 for a few key reasons. Acetylcholine is an important neurotransmitter involved numerous process involving exercise but one of the most important is that is involved in skeletal muscle innervation and muscle control. The second important factor is also related to acetylcholine fatigue and increase vigor during strenuous exercise. In the SuperPump 3.0 formula, it helps create a balanced stimulant “feel” so you can train harder and longer.
PIPER NIGRUM EXTRACT
When coming up with such an advanced formula, we wanted to make sure many of the natural components have optimal absorption. Bioperine is the “must have” bioavailability enhancer in the supplement world and we use the clinically researched dose in every scoop of SuperPump. It's a highly potent extract of Piper nigrum which is standardized for a component called piperine.
This revolutionary compound enhances bioavailability this by interacting with the ultrastructure of intestinal brush border and stimulating digestive enzymes. In various animal models piperine has been suggested to enhance the bioavailability of branch chain amino acids and vitamin B6.*